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【摘要】有研究报告指出：吸入胰岛素治疗Ⅱ型糖尿病，不但能有效控制血糖水平，对肺部也不会带来任何的副作用。
【全文】
Inhaled Insulin Shows Promise For Type 2 diabetes
A DGReview of :"Inhaled Human Insulin Treatment in Patients with Type 2 Diabetes Mellitus"
Annals of Internal Medicine
02/22/2001
By James Adams
Pulmonary delivery of insulin improved glycemic control in patients with type 2 diabetes and had no adverse pulmonary effects over a three-month treatment period, researchers report.
A randomized, open-label study to assess the efficacy and safety of inhaled insulin treatment was conducted by investigators from the University of Vermont College of Medicine in Burlington, Vermont; the University of Miami Medical Center in Miami, Florida; and Pfizer Central Research in Groton, Connecticut, all in the United States.
Twenty-six patients with type 2 diabetes underwent a screening visit, a four-week baseline phase and a 12-week treatment phase.
Treatment consisted of inhaled insulin before every meal with a bedtime injection of ultralente insulin. Patients performed home glucose monitoring and their insulin dose was adjusted weekly in accordance with a target preprandial plasma glucose level of 5.55 to 8.88 mmol/L.
Results showed that glycemic control significantly improved after inhaled insulin compared with baseline. The treatment was well-tolerated and pulmonary function tests detected no adverse effects after three months.
"Larger-scale studies are ongoing to provide long-term efficacy and safety data," the investigators report.
Ann Intern Med 2001; 134: 203-207. "Inhaled Human Insulin Treatment in Patients with Type 2 Diabetes Mellitus"
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